Which amendment protects citizens from unreasonable searches and seizures?

The 4th Amendment is the correct choice because it specifically addresses the rights of individuals against unreasonable searches and seizures by the government. It requires law enforcement to have probable cause and, in most cases, a warrant issued by a judge before they can search a person's property or seize their belongings. This amendment is rooted in the principle of protecting personal privacy and property, ensuring that individuals have a reasonable expectation of security in their homes and possessions.

The other amendments listed do not focus on search and seizure protections. The 2nd Amendment deals with the right to bear arms, the 5th Amendment addresses issues surrounding due process and self-incrimination, and the 6th Amendment guarantees rights related to criminal prosecutions, such as the right to a fair trial. Hence, the 4th Amendment is uniquely positioned to safeguard citizens from government overreach in their personal spaces.